I've only taken a major wrong turn a couple of times.
Once was with the family. We pulled off looking for an advertised McDonalds, took a wrong turn, and ended up at the gate to JPL. Same thing, we had to go onto the installation in order to turn around as we had a 35 foot 5th wheel behind us. The guards called us an escort vehicle and we had to go way in to where there was a culdasac to turn around. It was where the employee busses turn around apparently. Anyway, I think it helped that I had two young kids with me to ease their minds a bit, but it was a fun adventure. The Mickey Ds was just about 2 miles in the other direction.
The other time I was driving a race car semi in the "deep south". We pulled off to go to an advertised White Castle, as the directions said, but there was no restaurant.
No place for us to turn the rig around either, so we headed up the frontage road. So picture this. Two very white guys, in a sparklingly beautiful semi with pictures of race cars on the sides passing houses that were falling down with cars planted in the front yards, and all the "darker skinned" locals sitting on their porches with 40s in their hands(the beers, not guns) staring at us as we drove by!

Needless to say, we didn't ask for directions, and we didn't stop until we got back on the freeway.
After this incident, and another one in El Paso Texas the boss encouraged us to carry when we traveled.
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