I'm sure you know this but 925HP will destroy a factory 5.0 block in a heartbeat.
You will need a Boss block at a minimum preferably a DART. Single and twin set ups have both been done more than once and if you want a bolt on system call Wayne Pressley at Very Cool Parts and he will be happy to set you up with a tried and true system. As far as installation goes most people use the shorty headers installed facing forward and extend them with a bend pointing upwards that the turbos sit on from there it seems to be personal preference for the rest of the plumbing. Do a search and you will find a lot of good info.